Formulation and Evaluation of O/W Nanoemulsions of Caffeic Acid

Objective: To Formulate and Evaluate Nanoemulsions of Caffeic acid to overcome its poor aqueous solubility bioavailability. Methods: The caffeic nanoemulsions were prepared by spontaneous emulsification method through selection oil phase based on studies surfactant co-surfactant screening the basis their ability. components selected maximum in various media such as isopropyl myristate phase, tween 80 PEG 600 co-surfactant. Pseudo-ternary diagrams constructed optimize percentage oil, then evaluated for surface morphology, zeta potential, droplet size, pH, viscosity drug content. Result: formulated nanoemulsion showed -0.0468 mV potential with size below 100 nm, pH 5.9 9.3 cps. in-vitro release 98.76% 0.1N HCl while 98.57% phosphate buffer (pH 6.8) that was found be significantly higher than drug. Conclusion: improvement leading enhanced oral